THE ULTIMATE METHYLATED B COMPLEX
COMPLETE, BIOACTIVE & HIGHLY ABSORBABLE


Feeling drained, unfocused, or overwhelmed by daily stress? Approved Science® Methylated B Complex delivers full-spectrum support with all 8 essential B vitamins in their active, bioavailable forms. This targeted formula is designed to fuel energy, support mood, sharpen mental clarity, help protect memory, and promote metabolic efficiency, helping you feel and function at your best every day.
Unlike many standard formulas, this advanced complex features nutrients your body can absorb and use immediately, bypassing common genetic variations like MTHFR that can hinder absorption. The ingredients in our formula are backed by scientific studies published in respected journals such as Nutrients, Frontiers in Immunology, and Nutritional Neuroscience. Manufactured in an FDA-registered, cGMP-certified facility and backed by a 60-day money-back guarantee, it’s a formula you can feel confident choosing – designed to give your body the targeted support it needs to feel its best.
Backed By Science - Trusted For Results!
NEXT-LEVEL B COMPLEX
HERE'S WHY
When it comes to vitamin B supplements, quality and form matter – yet many formulas fall short. Some rely on cheaper, synthetic versions of B vitamins, such as folic acid or cyanocobalamin, which are poorly absorbed – especially for people with MTHFR gene variations. Others skip key nutrients like Betaine and Choline, or overload the formula with excessively high doses that the body can’t use efficiently.
We take a smarter approach. Our full-spectrum formula includes all 8 essential B vitamins in their active, methylated forms, so your body can use them right away. That includes a high absorption, patented Methylfolate, and our BalaSci™ Vitamin B12 Complex (a 50/50 blend of Methylcobalamin and Adenosylcobalamin) – for both methylation and energy support. We also include Betaine and Choline to enhance absorption and help your body make the most of every dose.
Backed by extensive research and formulated without unnecessary fillers or synthetic additives, our formula is designed to support energy, focus, mood, memory, and metabolic balance – every single day.
Approved Science® Methylated B Complex sets a new standard – because real results demand real quality!


OPTIMIZED METHYLATED B COMPLEX
THE #1 CHOICE FOR
ABSORPTION, POTENCY & RESULTS


PROVEN BENEFITS
POWERED BY SCIENCE
Boosts energy and stamina by helping convert food into fuel more efficiently.
Enhances mental clarity and focus with bioavailable forms of B12 and Folate.
Supports mood balance by aiding neurotransmitter production and stress response.
Promotes nervous system health to help maintain calm, coordination, and resilience.
Aids detoxification by supporting methylation pathways that remove cellular waste.
Helps regulate homocysteine to support heart, memory, and cognitive health.
Improves metabolic health and nutrient processing with added Betaine and Choline.
HOW IT WORKS
OUR FORMULA EXPLAINED
Approved Science® Methylated B Complex is formulated with active, bioavailable forms of all 8 essential B vitamins to help your body absorb and use them immediately. It’s designed to support energy, mood, cognitive function, memory, and metabolic balance – with optimized, science-backed doses and no synthetic fillers.
This formula features high-absorption Quatrefolic®, a patented folate that your body can use immediately without conversion. It also includes our BalaSci™ Vitamin B12 Complex, which is a 50/50 blend of Methylcobalamin and Adenosylcobalamin. These active forms support methylation – a key process that supports detoxification and mood balance – as well as cellular energy production. Unlike standard B supplements with less bioavailable forms, this blend promotes vitality and metabolic health more effectively.
Our advanced blend also includes Betaine and Choline – two key nutrients that enhance B vitamin function to support cleansing, nervous system health, and homocysteine balance. The formula is pure, thoughtfully dosed, and designed to give your body daily, long-term support.
This targeted complex works through four key actions – Absorb, Fuel, Regulate, and Perform – helping turn food into energy, support brain and nerve health, balance homocysteine, and build stress resilience.
For absorption, effectiveness, and ingredient quality, nothing on the market comes close to Approved Science® Methylated B Complex.
ACTION #1 ABSORB
Quatrefolic® [6S]–5–Methyltetrahydrofolate delivers folate in its active form, skipping the MTHFR conversion step that many struggle with. This ensures your body can readily use it for DNA repair, mood regulation, and methylation – a vital process that supports overall cellular health and function.
ACTION #2 FUEL
BalaSci™ Vitamin B12 Complex contains Methylcobalamin and Adenosylcobalamin in a balanced 50/50 mix. Methylcobalamin aids methylation for nerve health, while Adenosylcobalamin powers mitochondria to produce energy, helping you feel more alert and energized throughout the day.
ACTION #3 REGULATE
Betaine and Choline team up to optimize methylation, keeping homocysteine levels in check to support heart health, mental clarity, and memory. Elevated homocysteine has been linked to age-related cognitive decline, and lowering it may help protect long-term memory function. These nutrients also promote liver cleansing, neurotransmitter production, and oxidative stress reduction, helping the body stay balanced under stress.
ACTION #4 PERFORM
All 8 essential B vitamins, in their active forms, work together to convert food into fuel, support red blood cell formation, and maintain nerve function. This synergy boosts stamina, sharpens focus, and helps you stay mentally and physically strong throughout the day.
OUR METHYLATED VITAMIN B FORMULA
BIOAVAILABLE, COMPLETE & EFFECTIVE
INGREDIENTS
VITAMIN B1 (THIAMINE HCl)
Essential for converting food into energy. Plays a key role in nerve, muscle, and heart function.
VITAMIN B2 (RIBOFLAVIN-5-PHOSPHATE)
The active form of B2, ready for the body to use. Supports energy production, promotes cellular function, and helps lower homocysteine.
VITAMIN B3 (NIACINAMIDE)
A non-flushing form of B3 that supports NAD+ production for energy, DNA repair, and brain health.
VITAMIN B6 (PYRIDOXAL-5-PHOSPHATE)
The active form of B6, involved in over 100 enzyme reactions. Supports neurotransmitter function, energy metabolism, and homocysteine regulation.
FOLATE (QUATREFOLIC®)
A patented, active form of Folate (5-MTHF) with high bioavailability. Unlike standard folic acid, it bypasses common gene variants such as MTHFR, delivering pre-converted folate your body can use immediately. Supports methylation, mood, and heart health.


BALASCI™ VITAMIN B12 COMPLEX
A 50/50 blend of Methylcobalamin and Adenosylcobalamin – two active forms of Vitamin B12. Together, they provide full-spectrum support for methylation, energy, and healthy brain and nerve function.
VITAMIN B7 (BIOTIN)
Biotin supports healthy skin, hair, and nails, while aiding energy metabolism and gene regulation. It plays a key role in processing fats, carbs, and proteins, and helps maintain cellular function and methylation.
VITAMIN B5 (PANTOTHENIC ACID)
Supports the synthesis and function of coenzyme A, essential for fatty acid metabolism, adrenal health, and energy production.
CHOLINE (AS CHOLINE BITARTRATE)
Supports brain health and memory by aiding neurotransmitter production. Also involved in methylation and liver function.
BETAINE (TRIMETHYLGLYCINE)
A key methyl donor that works with folate and B12 for a complete approach to methylation and homocysteine balance. Supports detox, cardiovascular health, memory, and mood regulation.
B COMPLEX OR B BASIC? YOU DECIDE!


APPROVED SCIENCE METHYLATED B COMPLEX


IGENNUS SUPER B-COMPLEX


NEUROBIOLOGIX METHYLATION COMPLETE


INVITE HEALTH METHYL-B


OUR DAILY VITES L-METHYLFOLATE + COMPLEX
680mcg Quatrefolic® For Superior Folate Absorption
YES
NO
NO
NO
NO
Full B Complex Coverage - All 8 Essential Bs
YES
NO
NO
NO
NO
500mcg BalaSci™ B12 Complex - Bioactive & Balanced
YES
NO
NO
NO
NO
With Betaine (TMG) For Methylation Support
YES
NO
NO
YES
NO
Third-Party Tested
YES
NO
NO
YES
YES
Vegan Friendly
YES
YES
YES
NO
YES
GMP-Certified
YES
YES
YES
YES
YES
60-Day Money Back Guarantee
YES
NO
NO
NO
NO
Recommended Choice


What's THE WORD ON Approved Science® Methylated B Complex?
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TRY Approved Science® Methylated B Complex RISK FREE!
If at any time you are unsatisfied with a product you purchased from us, you may return any opened & unopened bottles within sixty (60) days for a full refund of the returned bottles, not including shipping.
The statements made on this website have not been evaluated by the Food & Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. Individual results may vary.
